Several approaches were utilized to identify drugs to block human immunodeficiency virus type 1 (HIV-1) replication in cell culture. Our studies show that palmitoil analogs of foscarnet can inhibit HIV reverse transcriptase and may be useful in the passage of the drug through the blood brain barrier. Chemically modified antisense oligonucleotides have been found to inhibit HIV replication in low concentration and without any toxic effect in cell culture.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP005535-05
Application #
3853482
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code