Human herpesvirus 8 (HHV-8): An immunofluorescence assay for latent HHV-8 antibodies revealed that U.S. homosexual men experienced an HHV-8 epidemic concurrent with the HIV epidemic in the early 1980s. HHV-8 infection was associated with numerous homosexual partners, and 35% of subjects with both HHV-8 and HIV developed Kaposi's sarcoma within 10 years. Five prototype assays for detection of HHV-8 antibodies were evaluated, and a combination of two (immunofluorescence for latent nuclear antibodies and enzyme immunoassay for antibodies against K8.1 recombinant protein) had particularly high sensitivity and specificity. Polyomaviruses: A study to examine reproducibility in detection of SV40 DNA in human mesothelioma or normal lung in nine laboratories was initiated. Hepatitis Viruses: Among subjects in the Multicenter Hemophilia Cohort Study, low levels of heterosexual transmission from men with hemophilia to their wives with hepatitis C virus (HCV) and hepatitis G virus (HGV). With HCV/HIV co-infection, atypical HCV antibody patterns were associated with an increased risk of end-stage liver disease. With HGV/HIV co-infection, AIDS risk was reduced 40% compared to HIV infection without HGV. In a case-control study in the Gambia of hepatocellular carcinoma associated with hepatitis B virus (HBV) and aflatoxin exposure, a technique was developed to detect the pathognomonic ser249 mutation of the p53 gene in plasma.
| Bekker, Vincent; O'Brien, Thomas R; Chanock, Stephen (2009) Population genetics and comparative genetics of CLDN1, a gene involved in hepatitis C virus entry. Hum Hered 67:206-16 |
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| Ioannidis, John P A; Boffetta, Paolo; Little, Julian et al. (2008) Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol 37:120-32 |
| O'Brien, Thomas R; Kachapati, Kritika; Zhang, Mingdong et al. (2007) HCV infection clearance with functional or non-functional caspase-12. Scand J Gastroenterol 42:416-7 |
| Kachapati, Kritika; O'Brien, Thomas R; Bergeron, Julie et al. (2006) Population distribution of the functional caspase-12 allele. Hum Mutat 27:975 |
| Blattner, William A; Oursler, Kris Ann; Cleghorn, Farley et al. (2004) Rapid clearance of virus after acute HIV-1 infection: correlates of risk of AIDS. J Infect Dis 189:1793-801 |
| Tanaka, Yasuhito; Pfeiffer, Ruth; Yeo, Anthony E T et al. (2004) PCR-probe capture hybridization assay and statistical model for SEN virus prevalence estimation. J Med Virol 73:123-30 |
| Hayes, R B; Pottern, L M; Strickler, H et al. (2000) Sexual behaviour, STDs and risks for prostate cancer. Br J Cancer 82:718-25 |
| Hisada, M; Rabkin, C S; Strickler, H D et al. (2000) Human papillomavirus antibody and risk of prostate cancer. JAMA 283:340-1 |
| Seeff, L B; Miller, R N; Rabkin, C S et al. (2000) 45-year follow-up of hepatitis C virus infection in healthy young adults. Ann Intern Med 132:105-11 |
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