Dietary exposures are believed to contribute to the majority of human cancers although most of the specific causal factors have not yet been identified. Since diet is a universal and modifiable exposure, research in this area offers the opportunity of significantly reducing cancer incidence and mortality. The Nutritional Epidemiology Branch conducts independent and collaborative research on the role of diet and nutritional status in cancer etiology. The Branch seeks to generate and test specific nutritional hypotheses, providing a scientific basis for public health recommendations and further understanding of the molecular basis of carcinogenesis. The Branch currently focuses on four broad exposure-drivenhypotheses involving: 1) energy balance (obesity and physical activity); 2) hyperinsulinemia and insulin resistance (taken broadly to include glycemic index and the IGF axis); 3) one-carbon metabolism; 4) meat, including potentially carcinogenic products of processing and cooking. The Branch also investigates other macronutrients and foods (fat, fiber, fruits and vegetables,) as well as micronutrients (vitamins D, E; calcium; selenium; carotenoids). Branch investigations in these priority areas use data on diet, supplement use, body size, physical activity, and blood- and tissue-based analytes. Many of these studies are also incorporate DNA-based genetic information. Because of the extensive biological research underlying contemporary nutrition, we frequently develop multidisciplinary studies with metabolic and/or molecular components. The role of nutrition is currently being evaluated in studies of lung, esophageal, stomach, colorectal, breast, endometrial, cervical, and prostate cancers as well as non-Hodgkin's lymphoma. Research approaches include descriptive analyses to generate hypotheses, analytic cohort and case-control investigations (with increasing emphasis on large prospective studies), nutritional intervention studies (clinical trials), metabolic studies, and biologic marker and genetic susceptibility projects. The Branch research program is designed to overcome several scientific obstacles to advancing the field: 1) Exposure assessment error. NEB, in conjunction with other NCI Divisions and other investigators around the world, has been conducting a series of methodologic studies to determine if we are missing key nutrition-cancer relations because of food frequency questionnaire measurement error and whether we need to use more intensive (and expensive) but more accurate assessment instruments. NEB is also expanding its work in nutrition-gene interactions. As we work through the problem of gene/SNP/haplotype selection in the face of complex biochemical pathways, NEB?s expanding work in nutrition-gene interactions can reveal ?sharpened? relative risks among the genetically susceptible (e.g., those with a particular allelic variant of a metabolizing enzyme-encoding gene) and thereby clarify the role of particular nutritional factors (alone or as part of complex dietary mixtures). 2) Inadequate exposure range. NEB?s investigations include existing (AARP, PLCO) and proposed (India) cohorts with wide reported intakes ranges for several key dietary factors. 3) Confounding. Relative risks for many nutritional factors are likely to be modest and easily confounded, even with adjustment for covariates. NEB approaches to this problem include: a) conducting or collaborating on randomized controlled trials, e.g., Polyp Prevention Trial, SELECT; b) using ?Mendelian randomization?, a strategy based on the premise that an association between an allelic variant mimicking, e.g., low micronutrient exposure is less likely to be biased by confounding (and measurement error) than an association with the dietary factor itself.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010127-08
Application #
6952503
Study Section
(NEB)
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2003
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Murphy, Gwen; Cross, Amanda J; Sansbury, Leah S et al. (2009) Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial. Int J Cancer 124:2148-51
Freedman, Neal D; Park, Yikyung; Subar, Amy F et al. (2008) Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study. Int J Cancer 122:2330-6
Abnet, Christian C; Freedman, Neal D; Hollenbeck, Albert R et al. (2008) A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. Eur J Cancer 44:465-71
Peters, Tricia M; Ekelund, Ulf; Leitzmann, Michael et al. (2008) Physical activity and mammographic breast density in the EPIC-Norfolk cohort study. Am J Epidemiol 167:579-85
Freedman, Neal D; Subar, Amy F; Hollenbeck, Albert R et al. (2008) Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study. Cancer Causes Control 19:459-67
Gierach, Gretchen L; Lacey Jr, James V; Schatzkin, Arthur et al. (2008) Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study. Breast Cancer Res 10:R38
Stolzenberg-Solomon, Rachael Z; Adams, Kenneth; Leitzmann, Michael et al. (2008) Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort. Am J Epidemiol 167:586-97
Schatzkin, Arthur (2007) Can biomarkers help us understand the nutritional and lifestyle factors important in cancer prognosis? J Nutr 137:249S-252S
Freedman, N D; Schatzkin, A; Leitzmann, M F et al. (2007) Alcohol and head and neck cancer risk in a prospective study. Br J Cancer 96:1469-74
Lim, Unhee; Weinstein, Stephanie; Albanes, Demetrius et al. (2006) Dietary factors of one-carbon metabolism in relation to non-Hodgkin lymphoma and multiple myeloma in a cohort of male smokers. Cancer Epidemiol Biomarkers Prev 15:1109-14

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