The main effort continues to be site-specific studies of tumor risk in a cohort of 120,000 Hiroshima and Nagasaki A-bomb survivors. Radiation-related tumors of the CNS, salivary gland and skin are largely confined to a relatively few cell types. Analyses of female breast cancer incidence show a high excess relative risk for women exposed before age 20, that continues undiminished over time following exposure. The only exception is an anomalously high excess for risk of early-onset cancer, diagnosed before age 35. At an NCI-sponsored, international workshop held in Hiroshima, it was agreed that this anomaly presents the most promising possibility of a radiation-host factor interaction involving a genetically predisposed subgroup. Actions being taken include (1) development of a family database for the study cohort, (2) cataloging of available tissue samples from relevant subjects, (3) immortalization of cell lines from stored and fresh blood specimens, and (4) closer involvement in the A-bomb survivor studies of scientists from the DCEG Genetics Program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010134-02
Application #
6161658
Study Section
Reproductive Biology Study Section (REB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Inai, Kouki; Shimizu, Yukiko; Kawai, Kioko et al. (2006) A pathology study of malignant and benign ovarian tumors among atomic-bomb survivors--case series report. J Radiat Res (Tokyo) 47:49-59
Fujita, Yasuyuki; Ito, Chikako; Mabuchi, Kiyohiko (2004) Surveillance of mortality among atomic bomb survivors living in the United States using the National Death Index. J Epidemiol 14:17-22
Preston, Dale L; Shimizu, Yukiko; Pierce, Donald A et al. (2003) Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 160:381-407
Land, Charles E; Tokunaga, Masayoshi; Koyama, Kojiro et al. (2003) Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res 160:707-17
Kabuto, M; Akiba, S; Stevens, R G et al. (2000) A prospective study of estradiol and breast cancer in Japanese women. Cancer Epidemiol Biomarkers Prev 9:575-9
Negri, E; Ron, E; Franceschi, S et al. (1999) A pooled analysis of case-control studies of thyroid cancer. I. Methods. Cancer Causes Control 10:131-42