Abstract

Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Some studies in this project address the role of specific infections in cancer, including hepatitis C virus in non-Hodgkin lymphoma, Chlamydia pneumoniae in lung cancer, and human papillomavirus in penile cancer. Other studies examine how general disturbances of immunity may also facilitate development of cancer, such as occurs in solid organ transplant recipients or end stage renal disease. Finally, the project also includes studies to elucidate the role of inflammation as a pathway to cancer, such as caused by chronic infection or autoimmune diseases. The studies are human population-based. Some studies use molecular markers, such as gene markers, serum or tissue markers of infection, and cytokine levels indicating inflammation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010150-08
Application #
7593185
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2007
Total Cost
$875,117
Indirect Cost

  Institution

Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Suneja, Gita; Shiels, Meredith S; Melville, Sharon K et al. (2013) Disparities in the treatment and outcomes of lung cancer among HIV-infected individuals. AIDS 27:459-68
Simard, Edgar P; Shiels, Meredith S; Bhatia, Kishor et al. (2012) Long-term cancer risk among people diagnosed with AIDS during childhood. Cancer Epidemiol Biomarkers Prev 21:148-54
Bhatia, Kishor; Shiels, Meredith S; Berg, Alexandra et al. (2012) Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpretations from a systematic literature review. Curr Opin Oncol 24:537-46
Simard, Edgar P; Pfeiffer, Ruth M; Engels, Eric A (2012) Mortality due to cancer among people with AIDS: a novel approach using registry-linkage data and population attributable risk methods. AIDS 26:1311-8
Persson, E Christina; Shiels, Meredith S; Dawsey, Sanford M et al. (2012) Increased risk of stomach and esophageal malignancies in people with AIDS. Gastroenterology 143:943-950.e2
Gadalla, S M; Preiss, L R; Eyster, M E et al. (2011) Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia. J Viral Hepat 18:161-9
Engels, Eric A (2010) Epidemiology of thymoma and associated malignancies. J Thorac Oncol 5:S260-5
Shiels, Meredith S; Goedert, James J; Moore, Richard D et al. (2010) Reduced risk of prostate cancer in U.S. Men with AIDS. Cancer Epidemiol Biomarkers Prev 19:2910-5
Shebl, Fatma M; Bhatia, Kishor; Engels, Eric A (2010) Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States. Int J Cancer 126:2503-8
Lanoy, E; Engels, E A (2010) Skin cancers associated with autoimmune conditions among elderly adults. Br J Cancer 103:112-4

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