We have previously identified that PGP9.5 is frequently overexpressed in lung cancers. We have also used yeast two-hybrid assay to identify genes that interact with PGP9.5. We recently showed that three genes, JAB1, UBC9 and RanBPM, are associated with PGP9.5 both in vitro and in vivo. Site-directed mutagenesis method is being used to determine the regions of PGP9.5 protein that interact with these factors. We are also also in the process of developing a mouse model that allows for tissue specific expression of PGP.5 in the small airway of the lung to determine the role of PGP9.5 in lung tumorigenesis.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010165-01
Application #
6556751
Study Section
(HGP)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code
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Monitto, Constance L; Dong, Seung-Myung; Jen, Jin et al. (2004) Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia. Clin Cancer Res 10:5862-9
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Player, Audrey; Gillespie, John; Fujii, Takeshi et al. (2003) Identification of TDE2 gene and its expression in non-small cell lung cancer. Int J Cancer 107:238-43