The dopamine transporter is a principal site for cocaine's rewarding and euphoric effects in the brain. Cocaine analog binding studies have revealed some details of the regional distribution of this transporter in untreated and in cocaine-treated brains. Studies completed during this FY have substantially enhanced information concerning the distribution of dopamine transporter protein, using immunohistochemical approaches. They also elucidated cell-group-specific alterations in transporter gene expression in animals withdrawn from a regimen of chronic cocaine administration.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000077-03
Application #
3752838
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code