Methamphetamine is an amphetamine-like stimulant with substantial abuse liability by the intravenous route. Recently, a new form of methamphetamine (""""""""ice"""""""") has been reported to be abused via the smoking route. This study will evaluate various chemical forms of methamphetamine in human volunteer subjects. Informed consent will be obtained and all procedures will be approved by the hospital Institutional Review Board. Methamphetamine will be administered by the smoking and intravenous routes. The pharmacokinetic profile will be determined by analysis of blood samples. The bioavailability and abuse liability of the smoked drug will be obtained by comparison to the intravenous route. Urine, saliva, and hair specimens will be collected for drug detection studies on methamphetamine. These studies will evaluate for the first time, the abuse potential of smoked methamphetamine and will allow drug detection methods to be developed for this new form of methamphetamine.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000328-02
Application #
3853753
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code