This project is a continuation of work initiated in 1993. Its point of departure is a central observation about drug-taking that has been substantiated in a broad range of studies. Namely, behavioral alternatives are among the determinants of drug use; this observation has received attention in laboratory-based animal and human studies. The underlying notion is that availability of competing alternative reinforcers decreases drug-seeking behavior maintained by a drug reinforcer. This strategy is part of behavioral treatments that encourage patients to broaden their behavioral repertoire as a means of decreasing the reinforcing effects of drugs. To investigate this notion from a complementary perspective, we analyzed data from an epidemiologic sample of more than 1500 urban middle-school students, who had completed private interviews/questionnaires in Spring 1993 as part of a longitudinal field trial being conducted by the Johns Hopkins Prevention Research Center in collaboration with the Baltimore City Public Schools. The assessment included a questionnaire to assess current behavioral repertoire. Drawing upon a dichotomous variable factor analysis of the repertoire data, we constructed seven indicators to represent different behavioral domains and then used multiple logistic regression to estimate associations with illicit drug use, holding constant age and sex. Illicit drug use was associated independently with less involvement in religious activities and greater involvement in work and other adult-like roles. These results corroborate other evidence on the potential etiologic significance of behavioral repertoire in relation to the risk of illicit drug use. Since these results do not address issues of temporal sequencing or other limitations of cross-sectional data, the association is being reexamined in the continuing study of this epidemiologic sample. More specifically, it now has become possible to determine the association of behavioral repertoires with initiation of drug use. In addition, a more complete analytic model is being used to reveal interactions among the behavioral domains as well as the influence of other risk or protective factors. During the past year, extension of this project to incorporate the prospective study data has revealed strong and independent associations between involvement in religious activities and the risk of starting illicit drug use during the study's one-year follow-up interval. The potential causal significance of the observed associations is supported by evidence from analyses in which the multiple logistic regression model has been used to hold constant alternative explanatory factors (neighborhood, school, familial, and individual). Further progress on this research front will help to clarify the issue of causal significance and to evaluate whether these new findings can be used to advantage in the design of NIDA-sponsored etiology and prevention research.
| London, Edythe D; Kohno, Milky; Morales, Angelica M et al. (2015) Chronic methamphetamine abuse and corticostriatal deficits revealed by neuroimaging. Brain Res 1628:174-85 |
| Dean, Andy C; Kohno, Milky; Morales, Angelica M et al. (2015) Denial in methamphetamine users: Associations with cognition and functional connectivity in brain. Drug Alcohol Depend 151:84-91 |
| Kohno, Milky; Ghahremani, Dara G; Morales, Angelica M et al. (2015) Risk-taking behavior: dopamine D2/D3 receptors, feedback, and frontolimbic activity. Cereb Cortex 25:236-45 |
| Kohno, Milky; Morales, Angelica M; Ghahremani, Dara G et al. (2014) Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence. JAMA Psychiatry 71:812-20 |
| Morales, Angelica M; Ghahremani, Dara; Kohno, Milky et al. (2014) Cigarette exposure, dependence, and craving are related to insula thickness in young adult smokers. Neuropsychopharmacology 39:1816-22 |
