Psychomotor stimulant drugs of abuse cause brain damage that is dependent on elevated body temperature. We have begun to examine brain temperature in association with self-administered drugs and other behaviors involving emotional arousal. We find that brain temperature is elevated 1-2? by the stress of handling and transport to the test cage, by mildly arousing tail pinch, and by exposure to another rat or a mouse. We find similar elevations during intravenous self-administration of heroin and cocaine. In each case brain temperature is higher than the temperature of the brain's blood supply, an in each case brain temperature increases before aortal blood temperature or muscle temperature increases. Thus emotional and drug-induced arousal can cause metabolically expensive neuronal activity that is capable of elevating brain temperature into the range of fever. Regional temperature measurements may offer an index of local metabolic activity that parallels some of the indices drawn from brain imaging studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000445-01
Application #
6535691
Study Section
(BNRB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response. eNeuro 4:
Kiyatkin, Eugene A; Ren, Suelynn E (2017) MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment. Curr Top Behav Neurosci 32:183-207
Wakabayashi, Ken T; Spekterman, Laurence; Kiyatkin, Eugene A (2016) Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain. Eur J Neurosci 43:1422-30
Edelman, E Jennifer; Dinh, An T; Moore, Brent A et al. (2012) Human immunodeficiency virus testing practices among buprenorphine-prescribing physicians. J Addict Med 6:159-65
Smirnov, Michael S; Kiyatkin, Eugene A (2008) Behavioral and temperature effects of delta 9-tetrahydrocannabinol in human-relevant doses in rats. Brain Res 1228:145-60
Wakazono, Y; Kiyatkin, E A (2008) Electrophysiological evaluation of the time-course of dopamine uptake inhibition induced by intravenous cocaine at a reinforcing dose. Neuroscience 151:824-35
Kiyatkin, Eugene A; Bae, David (2008) Behavioral and brain temperature responses to salient environmental stimuli and intravenous cocaine in rats: effects of diazepam. Psychopharmacology (Berl) 196:343-56
Kiyatkin, E A; Brown, P L (2007) I.v. cocaine induces rapid, transient excitation of striatal neurons via its action on peripheral neural elements: single-cell, iontophoretic study in awake and anesthetized rats. Neuroscience 148:978-95
Kiyatkin, Eugene A (2007) Physiological and pathological brain hyperthermia. Prog Brain Res 162:219-43
Kiyatkin, Eugene A (2007) Brain temperature fluctuations during physiological and pathological conditions. Eur J Appl Physiol 101:3-17

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