The principal objectives of this project are part of the ongoing effort identifying antiplaque and anticaries agents suitable for short-term clinical investigation, as well as to develop methods for assessing the clinical potential for these agents. The present study investigated the effects of DCPD treatments on the following: (a) uptake of flouride by molars; (b) caries incidence; and, (c) pH levels in dental plaque of rats wearing an intraoral fluoride releasing device (IFRD). The DCPD treatments significantly enhanced enamel uptake of fluride released by the IFRD. Rats wearing an IFRD exhibited a low caries incidence with or without a DCPD pretreatment. pH respones among groups were similar.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000112-12
Application #
4692601
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code