Abstract

The project consists of studies (1) to evalute the efficacy of two novel pain control agents, flurbiprofen and etidocaine; (2) to evaluate the interaction of flurbiprofen and etidocaine when given in combination to supress postoperative pain; (3) to evaluate the ability of a novel non-narcotic analgesic proglumide, to potentiate the analgesic activity of morphine. Both etidocaine and flurbiprofen resulted in greater pain suppression than standard drugs and the combination of the two resulted in greater analgesia than either drug alone. This combination possesses potential for improvement in the treatment of postoperative pain in that 67% of the sample reported little or no pain folowing the surgical removal of impacted molars, a procedure which normally results in moderate to severe postoperative pain. Proglumide is presently being evaluated in the oral surgery model to test its ability to potentiate morphine analgesia and evaluate its interaction with endogenous pain inhibitory substances such as beta-endorphin.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000286-06
Application #
4692627
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Wang, Xiao-Min; Wu, Tian-Xia; Hamza, May et al. (2007) Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain 128:136-47
Dworkin, Robert H; Turk, Dennis C; Farrar, John T et al. (2005) Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 113:9-19
Warburton, Gary; Nares, Salvador; Angelov, Nikola et al. (2005) Transcriptional events in a clinical model of oral mucosal tissue injury and repair. Wound Repair Regen 13:19-26
Lee, Y; Rodriguez, C; Dionne, R A (2005) The role of COX-2 in acute pain and the use of selective COX-2 inhibitors for acute pain relief. Curr Pharm Des 11:1737-55
Dionne, Raymond A; Bartoshuk, Linda; Mogil, Jeffrey et al. (2005) Individual responder analyses for pain: does one pain scale fit all? Trends Pharmacol Sci 26:125-30
Dionne, Raymond A; Haynes, Duncan; Brahim, Jaime S et al. (2004) Analgesic effect of sustained-release flurbiprofen administered at the site of tissue injury in the oral surgery model. J Clin Pharmacol 44:1418-24
Ta, Lauren E; Dionne, Raymond A (2004) Treatment of painful temporomandibular joints with a cyclooxygenase-2 inhibitor: a randomized placebo-controlled comparison of celecoxib to naproxen. Pain 111:13-21
Kim, Hyungsuk; Neubert, John K; San Miguel, Anitza et al. (2004) Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain 109:488-96
Phero, James C; Becker, Daniel E; Dionne, Raymond A (2004) Contemporary trends in acute pain management. Curr Opin Otolaryngol Head Neck Surg 12:209-16
Gordon, Sharon M; Dionne, Raymond A (2004) The integration of clinical research into dental therapeutics: the role of the astute clinician. J Am Dent Assoc 135:1537-42

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