Cell adhesion and morphogenesis are crucial events in craniofacial development, and errors can result in congenital anomalies. Related biological processes are being implicated in wound repair, tumor invasion and metastasis, and AIDS pathogenesis. We are characterizing the functions of certain key proteins that we hypothesize help to regulate cytoskeletal and signaling processes essential for development, malignancy, or AIDS. The mechanisms of salivary gland morphogenesis are under investigation. The roles of the tumor suppressor PTEN are being characterized in the regulation of cell migration and signal transduction. Roles of HIV Tat in regulating HIV pathogenesis are also being defined. We are also collaborating with the Oral and Craniofacial Genome Project to find new genes relevant to salivary and craniofacial development, and with GTTB, NIDCR to develop an artificial salivary gland. These studies should help to clarify mechanisms of pathogenesis and repair, and identify opportunities for prevention and therapeutic intervention in craniofacial congenital defects, cancer, HIV disease, and other disorders.
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| Wei, Cindy; Larsen, Melinda; Hoffman, Matthew P et al. (2007) Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Eng 13:721-35 |
| Green, J Angelo; Yamada, Kenneth M (2007) Three-dimensional microenvironments modulate fibroblast signaling responses. Adv Drug Deliv Rev 59:1293-8 |
| Stepp, Mary Ann; Liu, Yueyuan; Pal-Ghosh, Sonali et al. (2007) Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. J Cell Sci 120:2851-63 |
| Moon, Hye-Sung; Even-Ram, Sharona; Kleinman, Hynda K et al. (2006) Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells. Exp Cell Res 312:3425-31 |
| Devadas, Krishnakumar; Boykins, Robert A; Hardegen, Neil J et al. (2006) Selective side-chain modification of cysteine and arginine residues blocks pathogenic activity of HIV-1-Tat functional peptides. Peptides 27:611-21 |
| Larsen, Melinda; Artym, Vira V; Green, J Angelo et al. (2006) The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol 18:463-71 |
| Larsen, Melinda; Wei, Cindy; Yamada, Kenneth M (2006) Cell and fibronectin dynamics during branching morphogenesis. J Cell Sci 119:3376-84 |
| Even-Ram, Sharona; Artym, Vira; Yamada, Kenneth M (2006) Matrix control of stem cell fate. Cell 126:645-7 |
| Even-Ram, Sharona; Yamada, Kenneth M (2005) Cell migration in 3D matrix. Curr Opin Cell Biol 17:524-32 |
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