A study of the prevalence of early onset periodontitis in U.S. children aged 14 to 17 years has been completed and will be published in October, 1991. A major contract to relocate, reexamine and collect risk factor information on these children will begin in October, 1991. Research objectives are to: a) assess the progression of periodontal destruction among the cases of early onset periodontitis, b) characterize the microbial ecology of the sub-gingival plaque among persons with early onset periodontitis, c) describe periodontal destruction and the presence of biologic and non-biologic putative risk markers among the probands' similar aged siblings, and d) compare the presence and concentration of selected putative pathogens and host- resistance factors among individuals with early onset periodontitis to controls.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000544-01
Application #
3854275
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
National Institute of Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Diehl, S R; Wang, Y; Brooks, C N et al. (1999) Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol 70:418-30