Complement factors and breakdown products acting through cell surface membrane receptors block the differentiation of human B lymphocytes into immunoglobulin secreting cells. Complement receptors are associated with B cell surface immunoglobulin under certain circumstances. Furthermore, complement receptor expression is cell- cycle dependent. Monovalent ligands inhibit while polyvalent enhance the anti-IgM induced human B cell increase in intracytoplasmic calcium ion concentration and cell proliferation. Understanding of the mechanism of regulation of immune responses by complement and the role of complement receptors on human B cells is crucial for the understanding of the immunopathogenesis of autoimmune diseases since they are frequently associated with complement activation, depression of complement factor levels and changes in complement receptors.

Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost
City
State
Country
United States
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