It has been suggested on an experimental basis that elevated intraglomerular pressure leads to glomerulosclerosis. The regulation of angiotensin converting enzyme (ACE) production plays a central role in maintaining normal intraglomerular pressure. This project is designed to isolate the gene encoding ACE from mouse kidney to further study the regulation and expression of the enzyme.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code