The pathogenetic mechanisms underlying the diverse forms of murine lupus nephritis are being investigated. Renal morphology is being studied by light, immunofluorescence, immunoperoxidase and electron microscopy to delineate the types of glomerular and tubulo-interstitial lesions, as well as the characteristics of the immune deposits and the lymphoid cell proliferation. The impact of provocative maneuvers on serologic and renal histologic features is being examined to develop a model of a flare of lupus nephritis. Innovative treatment strategies will be studied as part of an ongoing effort to refine our approach to this disease.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code