Abstract

Acute renal failure has a high morbidity and mortality. We are working on the mechanism of action of two drugs(a-MSH and IL-10)that protect against renal injury in an animal model called ischemia-repercusion injury. We are also testing these agents in other forms of renal injury. Because this animal model does not reproduce many features of human acute renal failure, we are trying to find a better animal model. We have not suceeded yet.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK043403-01
Application #
6421397
Study Section
(MDB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Doi, Kent; Leelahavanichkul, Asada; Hu, Xuzhen et al. (2008) Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int 74:1017-25
Yasuda, Hideo; Leelahavanichkul, Asada; Tsunoda, Shinichiro et al. (2008) Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol 294:F1050-8
Doi, K; Hu, X; Yuen, P S T et al. (2008) AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. Kidney Int 73:1266-74
Dear, James W; Leelahavanichkul, Asada; Aponte, Angel et al. (2007) Liver proteomics for therapeutic drug discovery: inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure. Crit Care Med 35:2319-28
Holly, M K; Dear, J W; Hu, X et al. (2006) Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure. Kidney Int 70:496-506
Yasuda, H; Yuen, P S T; Hu, X et al. (2006) Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int 69:1535-42
Dear, J W; Yasuda, H; Hu, X et al. (2006) Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69:832-6
Jo, Sang-Kyung; Hu, Xuzhen; Yuen, Peter S T et al. (2004) Delayed DMSO administration protects the kidney from mercuric chloride-induced injury. J Am Soc Nephrol 15:2648-54
Deng, Jiangping; Hu, Xuzhen; Yuen, Peter S T et al. (2004) Alpha-melanocyte-stimulating hormone inhibits lung injury after renal ischemia/reperfusion. Am J Respir Crit Care Med 169:749-56
Morimoto, Motoko; Morimoto, Masahiro; Whitmire, Jeannette et al. (2004) Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response. J Immunol 172:2424-30

Showing the most recent 10 out of 19 publications