New data have been obtained on the role of microtubules in modulating cholesterol access to the mitochondrian of adrenal tumor cells in permanent culture. The stimulating effects of colchicine appear not to be mediated via changes in cAMP production as occurs in some cells but is consistent with facilitation of pregnenolone production when microtubules are destabilized and inhibition when they are stabilized by taxol.

Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
1986
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code