Abstract

The role of glycosylation in the secretion of thyroxine-binding globulin (TBG) was investigated by the use of swainsonine, an inhibitor of alpha-mannosidase in the Golgi. The drug caused incomplete glycosylation of TBG in cultured human hepatoma cells (Hep G2), accompanied by accelerated TBG secretion. This demonstrates that complete oligosaccharide processing is not required for TBG secretion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK045020-12
Application #
3941073
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code