The broad categories which are included in the project are: 1) Characterizing functionally the mechanism by which various substrates cross the plasma membrane of different mammalian cells; 2) identifying the metabolic and humoral factors which influence the transport of various substrates across the plasma membrane; 3) developing techniques which will distinguish between binding of a substrate to the membrane and translocation of the substrate across the membrane: 4) characterizing the mechanism by which the membrane transport of various substrates is altered in certain diseases; and 5) relating these alterations of membrane transport to the pathogenesis and clinical manifestations of the disease.

Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1990
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code