Mammalian 3',4'-dideoxynorlaudanosoline-1-carboxylic acids were synthesized and obtained as optically pure S-(+)- and R-(-)- hydrobromides. Configuration was established by X-ray analysis of the (+)-rotating hydantoin obtained besides the S-(+)- methylester in the fragmentation of the less polar urea in refluxing butanol. Presence of the compounds in phenyketonurics has been established and enantiospecificity will now be determined.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code