The focus of this project is to investigate at the molecular level the structural basis of meiotic chromosome metabolism and segregation in the yeast, Saccharomyces cerevisiae, and to compare it to that of the mouse and related mammalian species. A combined cytogenetic and immunochemical analysis is beng used to identify protein components of the synaptonemal complex and to determine their spatial distribution and organization. Methods of isolation and identification by light microscopy are being developed for the yeast synaptonemal complex, as well as for the meiotic spindle apparatus.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES021035-01
Application #
4693162
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code