Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES023006-01
Application #
3755412
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
Anna, Colleen H; Iida, Mari; Sills, Robert C et al. (2003) Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice. Toxicol Appl Pharmacol 190:135-45
Iida, Mari; Anna, Colleen H; Hartis, Jennifer et al. (2003) Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643. Carcinogenesis 24:757-70
Tam, Andrew S; Devereux, Theodora R; Patel, Arti C et al. (2003) Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors. Carcinogenesis 24:121-32
Devereux, Theodora R; Holliday, Wanda; Anna, Colleen et al. (2002) Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years. Carcinogenesis 23:1737-43
Herzog, Christopher R; Devereux, Theodora R; Pittman, Brian et al. (2002) Carcinogenic induction directs the selection of allelic losses in mouse lung tumorigenesis. Cancer Res 62:6424-9
Zhang, Z; Wang, Y; Vikis, H G et al. (2001) Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet 29:25-33
Devereux, T R; Stern, M C; Flake, G P et al. (2001) CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1. Mol Carcinog 31:68-73
Mingchao; Devereux, T R; Stockton, P et al. (2001) Loss of E-cadherin expression in gastric intestinal metaplasia and later stage p53 altered expression in gastric carcinogenesis. Exp Toxicol Pathol 53:237-46
Sills, R C; Hong, H L; Boorman, G A et al. (2001) Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years. Chem Biol Interact 135-136:373-86
Hayashi, S; Hong, H H; Toyoda, K et al. (2001) High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years. Toxicol Pathol 29:422-9

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