1) To assemble and follow a cohort of sisters of women who have had breast cancer.2) To identify genetic and environmental risk factors for breast cancer in a cohort of highly motivated women who are at increased risk.3) To identify genetic and environmental risk factors for other diseases in women.4) To identify affected sister pairs for studies of gene identification and association.5) To compare affected and unaffected sisters to identify risk factors for breast cancer.Accomplishments:This study is in the early planning stages. Focus groups have been conducted with geographically and ethnically diverse groups of women: African Americans sisters in Baltimore, Lesbian women in Washington DC, Latina sisters in San Francisco, and both sisters and survivors in North Carolina. The study plan has also been presented to several advocacy and special interest groups to assess interest and concerns. These groups and meetings have provided insights that will shape the ultimate design of the study. Currently, issues related to confidentiality and use of the Internet for data collection are being explored. Pilot tests will begin shortly. These will be designed to test specific recruitment and data collection strategies and to evaluate the expected sample sizes for specific substudies of interest. Data collection forms are being developed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES044005-02
Application #
6432300
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
Indirect Cost
Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Guinter, Mark A; Sandler, Dale P; McLain, Alexander C et al. (2018) An Estrogen-Related Dietary Pattern and Postmenopausal Breast Cancer Risk in a Cohort of Women with a Family History of Breast Cancer. Cancer Epidemiol Biomarkers Prev 27:1223-1226
Guinter, Mark A; McLain, Alexander C; Merchant, Anwar T et al. (2018) An estrogen-related lifestyle score is associated with risk of postmenopausal breast cancer in the PLCO cohort. Breast Cancer Res Treat 170:613-622
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Hooper, Laura G; Young, Michael T; Keller, Joshua P et al. (2018) Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women. Environ Health Perspect 126:027005
Guinter, Mark A; McLain, Alexander C; Merchant, Anwar T et al. (2018) A dietary pattern based on estrogen metabolism is associated with breast cancer risk in a prospective cohort of postmenopausal women. Int J Cancer 143:580-590
Felix, Janine F; Joubert, Bonnie R; Baccarelli, Andrea A et al. (2018) Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol 47:22-23u
Peipins, Lucy A; Rodriguez, Juan L; Hawkins, Nikki A et al. (2018) Communicating with Daughters About Familial Risk of Breast Cancer: Individual, Family, and Provider Influences on Women's Knowledge of Cancer Risk. J Womens Health (Larchmt) 27:630-639
Taylor, Kyla W; Troester, Melissa A; Herring, Amy H et al. (2018) Associations between Personal Care Product Use Patterns and Breast Cancer Risk among White and Black Women in the Sister Study. Environ Health Perspect 126:027011
White, Mary C; Soman, Ashwini; Weinberg, Clarice R et al. (2018) Factors associated with breast MRI use among women with a family history of breast cancer. Breast J 24:764-771
Parks, Christine G; D'Aloisio, Aimee A; Sandler, Dale P (2018) Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women. Am J Epidemiol 187:214-223

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