The hypothesis that magnetic fields influence breast cancer risk is based on the existence of a plausible mechanism related to the effect of magnetic fields on melatonin along with some limited epidemiologic data. The study has two following specific goals. 1. To determine if residential exposure to magnetic fields, as assessed by wiring configuration coding and direct measurements is associated with the risk of breast cancer. 2. A secondary hypothesis is that particular combinations of the alternating current (AC) magnetic field and the direct current (DC) magnetic field, increase the risk of breast cancer. This hypothesis was prompted by observations of biologic effects at particular combinations of the AC and DC fields in several experimental systems. The study is a case-control study nested within a cohort study of risk factors for breast and other cancers among approximately 54,000 African-American and Latino women in Los Angeles County. A technician visits each case and control to make measurements and administer an interview on residential history and sources of exposure to magnetic fields and light at night, an effector of melatonin. All cases of breast cancer diagnosed over the 5 year study period are being enrolled -- we estimate 400-500 cases. An equal number of controls are being enrolled. We have completed enrollment on over 300 cases and 300 controls and we will continue enrollment until Sept 1999. We have begun the analysis of the magnetic field data. We will be able to use our questionnaire data to examine the association between factors that influence melatonin homeostatis - shift work and light exposure - and breast cancer risk.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES049018-03
Application #
6106681
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
Langholz, Bryan; Ebi, Kristie L; Thomas, Duncan C et al. (2002) Traffic density and the risk of childhood leukemia in a Los Angeles case-control study. Ann Epidemiol 12:482-7
London, S J; Smart, J; Daly, A K (2000) Lung cancer risk in relation to genetic polymorphisms of microsomal epoxide hydrolase among African-Americans and Caucasians in Los Angeles County. Lung Cancer 28:147-55
London, S J; Yuan, J M; Chung, F L et al. (2000) Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 356:724-9
Gauderman, W J; McConnell, R; Gilliland, F et al. (2000) Association between air pollution and lung function growth in southern California children. Am J Respir Crit Care Med 162:1383-90
London, S J; Yuan, J M; Coetzee, G A et al. (2000) CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China. Cancer Epidemiol Biomarkers Prev 9:987-91
Ozbal, C C; Skipper, P L; Yu, M C et al. (2000) Quantification of (7S,8R)-dihydroxy-(9R,10S)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene adducts in human serum albumin by laser-induced fluorescence: implications for the in vivo metabolism of benzo[a]pyrene. Cancer Epidemiol Biomarkers Prev 9:733-9
London, S J; Romieu, I (2000) Health costs due to outdoor air pollution by traffic. Lancet 356:782-3
Berhane, K; McConnell, R; Gilliland, F et al. (2000) Sex-specific effects of asthma on pulmonary function in children. Am J Respir Crit Care Med 162:1723-30
Wilcox, A J; Taylor, J A; Sharp, R R et al. (1999) Genetic determinism and the overprotection of human subjects. Nat Genet 21:362
Ursin, G; London, S; Stanczyk, F Z et al. (1999) Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 91:1067-72

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