Genetic and environmental factors in cancer

London, Stephanie Joan

Abstract

I am collaborating with other NIEHS investigators on breast cancer research in the Sister Study. I am currently involved in analyses to examine SNPs that have emerged from whole genome association studies and to examine epigenetic factors in breast cancer. I am also interested in the study of factors influencing survival and contributed to the development of an instrument to follow-up subjects who develop breast cancer. In addition to the main Sister Study, I am a collaborator on an ancillary project called the Two Sister Study lead by Dr. Clarice Weinberg to add sample and exposure data collection on sisters with early onset breast cancer of participants in the cohort. Dr. Weinberg received external funding for this project from the Komen Foundation.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Intramural Research (Z01)
• Project #: 1Z01ES101574-06
• Application #: 7734523
• Support Year: 6
• Fiscal Year: 2008
• Total Cost: $102,990

Institution

• Name: National Institute of Environmental Health Sciences
• Country: United States

Publications

Raimondi, S; Paracchini, V; Autrup, H et al. (2006) Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review. Am J Epidemiol 164:1027-42

Raimondi, Sara; Boffetta, Paolo; Anttila, Sisko et al. (2005) Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study. Mutat Res 592:45-57

London, Stephanie J; Pogoda, Janice M; Hwang, Katherine Liao et al. (2003) Residential magnetic field exposure and breast cancer risk: a nested case-control study from a multiethnic cohort in Los Angeles County, California. Am J Epidemiol 158:969-80

Lee, Won Jin; Brennan, Paul; Boffetta, Paolo et al. (2002) Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review. Biomarkers 7:230-41

Benhamou, Simone; Lee, Won Jin; Alexandrie, Anna-Karin et al. (2002) Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. Carcinogenesis 23:1343-50

London, Stephanie J; Yuan, Jian-Min; Travlos, Gregory S et al. (2002) Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. J Natl Cancer Inst 94:749-54

Ursin, Giske; London, Stephanie; Yang, Dongyun et al. (2002) Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. Breast Cancer Res Treat 72:139-43