Abstract

The interstitial lung disease project seeks to uncover the genetic and environmental determinants of interstitial lung disease (ILD). Our ongoing effort to establish human disease/environmental exposure DNA collections, coupled with high-throughput resequencing, high-throughput genotyping, gene expression analysis by means of microarray, and Serial Analysis of Gene E Expression (SAGE) will allow us to explore relationships between specific environmental exposures and candidate susceptibility genes. In the past year we have moved closer to the identification of specific candidate genes responsible for susceptibility to ILD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES101947-04
Application #
7734546
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2008
Total Cost
$128,034
Indirect Cost

  Institution

Name
National Institute of Environmental Health Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Seibold, Max A; Wise, Anastasia L; Speer, Marcy C et al. (2011) A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 364:1503-12
Garantziotis, Stavros; Hollingsworth, John W; Ghanayem, Rami B et al. (2007) Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury. J Immunol 179:4187-92
Yang, Ivana V; Burch, Lauranell H; Steele, Mark P et al. (2007) Gene expression profiling of familial and sporadic interstitial pneumonia. Am J Respir Crit Care Med 175:45-54
Martinez, Fernando J; Safrin, Sharon; Weycker, Derek et al. (2005) The clinical course of patients with idiopathic pulmonary fibrosis. Ann Intern Med 142:963-7
Lynch, David A; David Godwin, J; Safrin, Sharon et al. (2005) High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med 172:488-93
Burch, Lauranell H; Schwartz, David A (2005) Finding fibrosis genes: the lung. Methods Mol Med 117:293-313
King Jr, Talmadge E; Safrin, Sharon; Starko, Karen M et al. (2005) Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis. Chest 127:171-7
Steele, Mark P; Speer, Marcy C; Loyd, James E et al. (2005) Clinical and pathologic features of familial interstitial pneumonia. Am J Respir Crit Care Med 172:1146-52
Strieter, Robert M; Starko, Karen M; Enelow, Richard I et al. (2004) Effects of interferon-gamma 1b on biomarker expression in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 170:133-40
Garantziotis, Stavros; Steele, Mark P; Schwartz, David A (2004) Pulmonary fibrosis: thinking outside of the lung. J Clin Invest 114:319-21