IL-2-PE40 is a recombinant chimeric protein composed of interleukin-2 (IL-2) and of Pseudomonas endotoxin (PE40), minus its cell-binding domain. This toxin, once internalized, kills cells by irreversibly inhibiting protein synthesis. Hence, cells bearing IL-2 receptors on their surface, which are prime targets for this toxin, can be effectively removed from an organism without producing too many untoward side effects. In experimental autoimmune uveitis (EAU), T cells play a major role. Once activated, these T cells express on their cell surface IL-2 receptors, which can be targeted by the chimeric toxin and eliminated. We have demonstrated that this toxin is able to reduce significantly the incidence and severity of experimentally induced uveitis. IL-2PE40 is also able to reduce the incidence and severity of corneal graft rejection following systemic administration of the toxin.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000267-01
Application #
3877082
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1990
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code