Dietary supplementation with 1.5-2.0 g elemental calcium per day during pregnancy has been found to reduce the incidence of hypertensive disorders of pregnancy in several small randomized trials. It is proposed to test this effect in a randomized, double-blind, placebo-controlled trial conducted in five collaborating clinical centers. Calcium or placebo will be administered to 4500 nulliparous patients who begin treatment during weeks 14-22 of gestation. Therapy will be continued until the termination of pregnancy. Primary endpoints of the study are preeclampsia, eclampsia, and HELLP syndrome. Birth weight will be an important secondary outcome. Contracts were awarded to five clinical centers (U. Alabama, Case Western Reserve U., U. New Mexico, Oregon U., U. Tennessee) and to the data coordinating center (The Emmes Corp.) during March and April 1991.
| England, Lucinda J; Grauman, Alyssa; Qian, Cong et al. (2007) Misclassification of maternal smoking status and its effects on an epidemiologic study of pregnancy outcomes. Nicotine Tob Res 9:1005-13 |
| Tjoa, May Lee; Levine, Richard J; Karumanchi, S Ananth (2007) Angiogenic factors and preeclampsia. Front Biosci 12:2395-402 |
| Rana, Sarosh; Karumanchi, S Ananth; Levine, Richard J et al. (2007) Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia. Hypertension 50:137-42 |
| Levine, Richard J; Lam, Chun; Qian, Cong et al. (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992-1005 |
| Levine, Richard J; Qian, Cong; Maynard, Sharon E et al. (2006) Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women. Am J Obstet Gynecol 194:1034-41 |
| Bdolah, Yuval; Palomaki, Glenn E; Yaron, Yuval et al. (2006) Circulating angiogenic proteins in trisomy 13. Am J Obstet Gynecol 194:239-45 |
| Signore, Caroline; Mills, James L; Qian, Cong et al. (2006) Circulating angiogenic factors and placental abruption. Obstet Gynecol 108:338-44 |
| Levine, Richard J; Thadhani, Ravi; Qian, Cong et al. (2005) Urinary placental growth factor and risk of preeclampsia. JAMA 293:77-85 |
| Levine, Richard J; Karumanchi, S Ananth (2005) Circulating angiogenic factors in preeclampsia. Clin Obstet Gynecol 48:372-86 |
| Levine, Richard J; Qian, Cong; Leshane, Erik S et al. (2004) Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia. Am J Obstet Gynecol 190:707-13 |
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