Abstract

A major project of this section is the development of new statistical genetics methodology as prompted by the needs of our applied studies. This year Dr. Bailey-Wilson worked on development of several new methods. The first, in collaboration with Dr. Gloria Ho, is an extension of the Transmission Disequilibrium Test (TDT) and the Sibling-Transmission Disequilibrium Test (S-TDT) and the combined test (C-TDT) to traits that are caused, in whole or in part, by loci on the X chromosome. This work was published in the American Journal of Human Genetics in 2000. The second project, in collaboration with Dr. Silvano Presciuttina from the University of Pisa, is the development of a stepwise procedure for using a few genetic markers at each step to try to differentiate siblings from unrelated individuals. This methodology has applications in linkage analysis and in forensics. A new version of this method using likelihood methods has been developed this year and a a manuscript is in preparation. The third project, in collaboration with Dr. Jim Malley at CIT, NIH, is the development of a new method for family based association tests that appears considerably more powerful than the TDT but more robust to false positives than is case-control association. These projects are ongoing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000153-02
Application #
6830079
Study Section
(IDRB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Human Genome Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Holzinger, Emily R; Verma, Shefali S; Moore, Carrie B et al. (2017) Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min 10:25
Kim, Yoonhee; Doan, Betty Q; Duggal, Priya et al. (2007) Normalization of microarray expression data using within-pedigree pool and its effect on linkage analysis. BMC Proc 1 Suppl 1:S152
NCI-NHGRI Working Group on Replication in Association Studies; Chanock, Stephen J; Manolio, Teri et al. (2007) Replicating genotype-phenotype associations. Nature 447:655-60
Mandal, Diptasri M; Sorant, Alexa J M; Atwood, Larry D et al. (2006) Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment. BMC Genet 7:21
Manolio, Teri A; Bailey-Wilson, Joan E; Collins, Francis S (2006) Genes, environment and the value of prospective cohort studies. Nat Rev Genet 7:812-20
Marroni, F; Pichler, I; De Grandi, A et al. (2006) Population isolates in South Tyrol and their value for genetic dissection of complex diseases. Ann Hum Genet 70:812-21
Gillanders, E M; Pearson, J V; Sorant, A J M et al. (2006) The value of molecular haplotypes in a family-based linkage study. Am J Hum Genet 79:458-68
Doan, Betty Q; Sorant, Alexa J M; Frangakis, Constantine E et al. (2006) Covariate-based linkage analysis: application of a propensity score as the single covariate consistently improves power to detect linkage. Eur J Hum Genet 14:1018-26
Bailey-Wilson, Joan; Almasy, Laura; de Andrade, Mariza et al. (2005) Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans. BMC Genet 6 Suppl 1:S1
Klein, Alison; Tsai, Ya-Yu; Duggal, Priya et al. (2005) Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits. BMC Genet 6 Suppl 1:S20

Showing the most recent 10 out of 21 publications