Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. Affected sibling pairs and densely affected multi-generation families have been recruited from Colombia, South America, the US, and Germany. A genome-wide search for loci linked to ADHD has been completed and we have identified at least five regions in the human genome that contain genes to may contribute to ADHD (Arcos-Burgos et al. 2004). To date, we have complete clinical information on a total of over 600 small and large, multi-generation families, respectively (Palacio et al., 2004; Jain et al. 2006). We are now in the process to use the clinical and genome data to search for genes that contribute to ADHD

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000175-08
Application #
7594313
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2007
Total Cost
$1,523,000
Indirect Cost

  Institution

Name
National Human Genome Research Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Trujillo-Orrego, N; Pineda, D A; Arango, C P et al. (2009) [Attention deficit hyperactivity behavioral phenotype dimensions of adults from Antioquian families using the Wender-Utah Scale -Spanish version] Rev Neurol 48:400-6
Jain, Mahim; Palacio, Luis Guillermo; Castellanos, F Xavier et al. (2007) Attention-deficit/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility Loci. Biol Psychiatry 61:1329-39
Russell, Heather F; Wallis, Deeann; Mazzocco, Michele M M et al. (2006) Increased prevalence of ADHD in Turner syndrome with no evidence of imprinting effects. J Pediatr Psychol 31:945-55
Lee, J S; Tartaglia, M; Gelb, B D et al. (2005) Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndrome. J Med Genet 42:e11
Wattendorf, Daniel J; Muenke, Maximilian (2005) Prader-Willi syndrome. Am Fam Physician 72:827-30
Wattendorf, Daniel J; Muenke, Maximilian (2005) Diagnosis and management of fragile X syndrome. Am Fam Physician 72:111-3
Edison, Robin J; Muenke, Maximilian (2005) Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly. N Engl J Med 352:2759
Wattendorf, Daniel J; Muenke, Maximilian (2005) Fetal alcohol spectrum disorders. Am Fam Physician 72:279-82, 285
Roessler, Erich; Ermilov, Alexandre N; Grange, Dorothy Katherine et al. (2005) A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet 14:2181-8
McPherson, Elizabeth; Huff, Dale; Dunn, Jeanette et al. (2004) Anomalies of the forebrain with radial limb defects: Garcia-Lurie-Steinfeld syndrome? Birth Defects Res A Clin Mol Teratol 70:537-44

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