Dr. Bailey-Wilson is a member of a collaborative study of Attention Deficit Hyperactivity Disorder, collaborating with Drs. Max Muenke and Kate Berg of NHGRI and Dr. Mauricio Arcos-Burgos of NHGRI and University of Antioquia, Columbia. Dr. Bailey-Wilson's role is to help with study design and to serve as statistical geneticist on the project. In the past, we have performed power studies of many large pedigrees from Columbia, showing that there will be adequate power in a linkage study to detect genes of moderate to large effect, even in the presence of heterogeneity. Dr. Bailey-Wilson also advises the other collaborators about the types of pedigree structures that are particularly informative for linkage studies. A paper detailing the study design and the simulation has been published previously. In this fiscal year, linkage and association studies have been published on the first set of large pedigrees from Columbia for markers in several candidate loci. Genome-wide scan genotyping and inkage analysis has been completed on the first set of families followed by finemapping. Several papers are in press reporting the results of these studies. Studies are ongoing to followup these results.
| Arcos-Burgos, M; Castellanos, F X; Konecki, D et al. (2004) Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate. Mol Psychiatry 9:252-9 |
| Arcos-Burgos, M; Castellanos, F X; Lopera, F et al. (2002) Attention-deficit/hyperactivity disorder (ADHD): feasibility of linkage analysis in a genetic isolate using extended and multigenerational pedigrees. Clin Genet 61:335-43 |
