Abstract

The epidermis is a self-renewing tissue, which provides a natural barrier between the organism and the environment. Our research focuses on the dynamic process by which the epidermis maintains the proper balance between proliferation and differentiation during prenatal development and adult stages. Combining classical genetics and modern tools of genomics, we investigate and model the function of DNA binding proteins and pharmacologic agents. We seek to answer fundamental questions about the mechanism by which these epidermal cells maintain this balance during development, after trauma or wounding and throughout life. This work has implications for premature infants, psoriasis and atopic dermatitis (eczema), with long term significance for asthma and hay fever.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000180-06
Application #
7316027
Study Section
(GMBB)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Human Genome Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Choi, Yeon Sook; Cheng, Jun; Segre, Julie et al. (2008) Generation and analysis of Elf5-LacZ mouse: unique and dynamic expression of Elf5 (ESE-2) in the inner root sheath of cycling hair follicles. Histochem Cell Biol 129:85-94
Grice, Elizabeth A; Kong, Heidi H; Renaud, Gabriel et al. (2008) A diversity profile of the human skin microbiota. Genome Res 18:1043-50
de Guzman Strong, Cristina; Segre, Julia A (2008) Navigating the genome. J Cell Sci 121:921-3
Kharas, Michael G; Yusuf, Isharat; Scarfone, Vanessa M et al. (2007) KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood 109:747-55
List, Karin; Currie, Brooke; Scharschmidt, Tiffany C et al. (2007) Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem 282:36714-23
Teng, Andy; Nair, Mahalakshmi; Wells, Julie et al. (2007) Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis. Biochim Biophys Acta 1772:89-95
Feinberg, Mark W; Wara, Akm Khyrul; Cao, Zhuoxiao et al. (2007) The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J 26:4138-48
Segre, Julia A (2006) Epidermal barrier formation and recovery in skin disorders. J Clin Invest 116:1150-8
Djalilian, Ali R; McGaughey, David; Patel, Satyakam et al. (2006) Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest 116:1243-53
Segre, Julia A (2006) Epidermal differentiation complex yields a secret: mutations in the cornification protein filaggrin underlie ichthyosis vulgaris. J Invest Dermatol 126:1202-4

Showing the most recent 10 out of 11 publications