Abstract

During the past year we have contructed a combined x-ray and MRI interventional suite for clinical and animal research, including a custom image-reconstruction and guidance system. We have demonstrated non-toxic labeling of adult-derived stem cells and serial in-vivo surveillance of injected stem cells into the myocardium of swine using MRI. We have demonstrated direct fluoroscopic MRI targeted delivery of adult-derived stem cells into the borders of myocardial infarctions in swine. We have begun investigation of other interventional MRI applications including aortic aneurysm endograft therapy using fluoroscopic MRI. We have tested the safety of intravascular MRI in human research subjects. Studies are underway to test and develop other novel applications of fluoroscopic MRI, including cardiac valve repair and recanalization of total vascular occlusions. Finally we have begun preparation for two human research trials. One will test the safety and provisional efficacy of parenteral allogeneic adult-derived stem cell therapy for subjects recovering from a myocardial infarction. Another will test the safety and provisional efficacy of novel transcriptional regulatory factor to induce therapeutic angiogenesis, as assessed using MRI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL005062-01
Application #
6822883
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ramasawmy, Rajiv; Rogers, Toby; Alcantar, Miguel A et al. (2018) Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation. J Cardiovasc Magn Reson 20:62
Campbell-Washburn, Adrienne E; Rogers, Toby; Stine, Annette M et al. (2018) Right heart catheterization using metallic guidewires and low SAR cardiovascular magnetic resonance fluoroscopy at 1.5 Tesla: first in human experience. J Cardiovasc Magn Reson 20:41
Rogers, Toby; Ratnayaka, Kanishka; Khan, Jaffar M et al. (2017) CMR fluoroscopy right heart catheterization for cardiac output and pulmonary vascular resistance: results in 102 patients. J Cardiovasc Magn Reson 19:54
Rogers, Toby; Mahapatra, Srijoy; Kim, Steven et al. (2016) Transcatheter Myocardial Needle Chemoablation During Real-Time Magnetic Resonance Imaging: A New Approach to Ablation Therapy for Rhythm Disorders. Circ Arrhythm Electrophysiol 9:e003926
Rogers, Toby; Ratnayaka, Kanishka; Karmarkar, Parag et al. (2016) Real-time magnetic resonance imaging guidance improves the diagnostic yield of endomyocardial biopsy. JACC Basic Transl Sci 1:376-383
Campbell-Washburn, Adrienne E; Xue, Hui; Lederman, Robert J et al. (2016) Real-time distortion correction of spiral and echo planar images using the gradient system impulse response function. Magn Reson Med 75:2278-85
McGuirt, Delaney; Mazal, Jonathan; Rogers, Toby et al. (2016) X-ray Fused With Magnetic Resonance Imaging to Guide Endomyocardial Biopsy of a Right Ventricular Mass. Radiol Technol 87:622-6
Ratnayaka, Kanishka; Rogers, Toby; Schenke, William H et al. (2016) Magnetic Resonance Imaging-Guided Transcatheter Cavopulmonary Shunt. JACC Cardiovasc Interv 9:959-70
Mazal, Jonathan R; Rogers, Toby; Schenke, William H et al. (2016) Interventional-Cardiovascular MR: Role of the Interventional MR Technologist. Radiol Technol 87:261-70
Campbell-Washburn, Adrienne E; Faranesh, Anthony Z; Lederman, Robert J et al. (2015) Magnetic Resonance Sequences and Rapid Acquisition for MR-Guided Interventions. Magn Reson Imaging Clin N Am 23:669-79

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