Abstract

A sufficiently extensive cDNA clone of rat liver phenylalanine hydroxylase has been isolated and sequenced. A composite DNA molecule containing this cDNA and the E. coli lac promoter, operator, and translation initiation site has been constructed and placed in a host that is inducible for this operon. Elevated phenylalanine hydroxylase mRNA levels have been observed in diabetic rats.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH001040-04
Application #
3944677
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code