We have studied the neurophysiology of the frontal lobe of primates by developing novel behavioral methods. These methods distinguish neuronal activity related to sensory and perceptual processes from those involved in the selection and control of behavior by controlling covert as well as overt behavioral variables. Specifically, during the past year we have continued testing the hypothesis that the premotor areas, such as the supplementary eye field (SEF), play a role in the selection of action on the basis of nonstandard stimulus-response associations, whereas other areas, perhaps including the primary motor cortex (M1), plays a role in the standard mapping of inputs to outputs. This fiscal year, we have focused on two kinds of motor learning: conditional oculomotor learning and skill learning. We have also been engaged in theoretical work that attempts to comprehend the cooperative actions of distributed neural modules in the selection and control of behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH001092-17
Application #
5203683
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1995
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Nougaret, Simon; Genovesio, Aldo (2018) Learning the meaning of new stimuli increases the cross-correlated activity of prefrontal neurons. Sci Rep 8:11680
Marcos, Encarni; Nougaret, Simon; Tsujimoto, Satoshi et al. (2018) Outcome Modulation Across Tasks in the Primate Dorsolateral Prefrontal Cortex. Neuroscience 371:96-105
Marcos, Encarni; Tsujimoto, Satoshi; Genovesio, Aldo (2016) Event- and time-dependent decline of outcome information in the primate prefrontal cortex. Sci Rep 6:25622
Marcos, Encarni; Genovesio, Aldo (2016) Determining Monkey Free Choice Long before the Choice Is Made: The Principal Role of Prefrontal Neurons Involved in Both Decision and Motor Processes. Front Neural Circuits 10:75
Genovesio, Aldo; Cirillo, Rossella; Tsujimoto, Satoshi et al. (2015) Automatic comparison of stimulus durations in the primate prefrontal cortex: the neural basis of across-task interference. J Neurophysiol 114:48-56
Genovesio, Aldo; Tsujimoto, Satoshi; Navarra, Giulia et al. (2014) Autonomous encoding of irrelevant goals and outcomes by prefrontal cortex neurons. J Neurosci 34:1970-8
Tsujimoto, Satoshi; Genovesio, Aldo; Wise, Steven P (2012) Neuronal activity during a cued strategy task: comparison of dorsolateral, orbital, and polar prefrontal cortex. J Neurosci 32:11017-31
Genovesio, Aldo; Tsujimoto, Satoshi; Wise, Steven P (2012) Encoding goals but not abstract magnitude in the primate prefrontal cortex. Neuron 74:656-62
Genovesio, Aldo; Tsujimoto, Satoshi; Wise, Steven P (2011) Prefrontal cortex activity during the discrimination of relative distance. J Neurosci 31:3968-80
Tsujimoto, Satoshi; Genovesio, Aldo; Wise, Steven P (2011) Comparison of strategy signals in the dorsolateral and orbital prefrontal cortex. J Neurosci 31:4583-92

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