Under NCT03388606, we have: 1. Screened: 449 potential MDD patients, 120 HVs 2. Enrolled: 80 MDD patients, 70 HVs (including in other protocols) 3. Scanned: 255 MDD and HVs in total, including repeated scans on same individual as part of follow-up. 4. Increased inpatient activity: this protocol has already accounted for nearly 300 inpatient days, an 84% increase in activity relative to FY17 for the same time period. 5. Increased outpatient activity: this protocol has seen over 200 more outpatient visits than the program recorded in FY17 for the same time period. 6. Have published as first, last or co-author 20 more papers since last year. The most notable include two last-author papers in the American Journal of Psychiatry (Pan et al., 2017, Keren et al., 2018) and another last authored methodological paper on the reliability of the reward prediction error in Neuroimage (Keren et al., 2018).

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U.S. National Institute of Mental Health
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Villalta, L; Smith, P; Hickin, N et al. (2018) Emotion regulation difficulties in traumatized youth: a meta-analysis and conceptual review. Eur Child Adolesc Psychiatry 27:527-544
Brislin, Sarah J; Patrick, Christopher J; Flor, Herta et al. (2018) Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project. Assessment :1073191118759748
Keren, Hanna; O'Callaghan, Georgia; Vidal-Ribas, Pablo et al. (2018) Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies. Am J Psychiatry :appiajp201817101124
Asarnow, Joan; Bloch, Michael H; Brandeis, Daniel et al. (2018) Special Editorial: Open science and the Journal of Child Psychology & Psychiatry - next steps? J Child Psychol Psychiatry 59:826-827
Stringaris, Argyris; Vidal-Ribas, Pablo; Brotman, Melissa A et al. (2018) Practitioner Review: Definition, recognition, and treatment challenges of irritability in young people. J Child Psychol Psychiatry 59:721-739
Vidal-Ribas, Pablo; Brotman, Melissa A; Salum, Giovanni A et al. (2018) Deficits in emotion recognition are associated with depressive symptoms in youth with disruptive mood dysregulation disorder. Depress Anxiety 35:1207-1217
Daley, David; Van Der Oord, Saskia; Ferrin, Maite et al. (2018) Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder. J Child Psychol Psychiatry 59:932-947
Kircanski, Katharina; White, Lauren K; Tseng, Wan-Ling et al. (2018) A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 75:631-639
Keren, Hanna; Chen, Gang; Benson, Brenda et al. (2018) Is the encoding of Reward Prediction Error reliable during development? Neuroimage 178:266-276
Barker, Edward D; Walton, Esther; Cecil, Charlotte A M et al. (2018) A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder. Child Dev 89:1839-1855

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