Under NCT00025935, we have already screened over 150 patients with depression and have scanned over 35 participants with depression, other conditions, and healthy volunteers. We have analyzed existing data and have already published papers since the start of my tenure here. On the methodological side: we have just completed a paper measuring the reliability of the reward prediction error signal in a reward task. We have included a new metric, namely intrinsic functional connectivity, and published a paper about its role in depression. We have completed the analysis of a double-blind, placebo controlled pharmaco-imaging study and are about to submit the data for publication. We have completed a meta-analysis of EEG and fMRI study related to reward processing in depression and are about to submit the data for publication.

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1
Fiscal Year
2017
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U.S. National Institute of Mental Health
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Kircanski, Katharina; White, Lauren K; Tseng, Wan-Ling et al. (2018) A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 75:631-639
Keren, Hanna; Chen, Gang; Benson, Brenda et al. (2018) Is the encoding of Reward Prediction Error reliable during development? Neuroimage 178:266-276
Barker, Edward D; Walton, Esther; Cecil, Charlotte A M et al. (2018) A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder. Child Dev 89:1839-1855
Humphreys, Kathryn L; Schouboe, Sophie N F; Kircanski, Katharina et al. (2018) Irritability, Externalizing, and Internalizing Psychopathology in Adolescence: Cross-Sectional and Longitudinal Associations and Moderation by Sex. J Clin Child Adolesc Psychol :1-9
Wesselhoeft, Rikke; Stringaris, Argyris; Sibbersen, Christian et al. (2018) Dimensions and subtypes of oppositionality and their relation to comorbidity and psychosocial characteristics. Eur Child Adolesc Psychiatry :
Fernández de la Cruz, Lorena; Vidal-Ribas, Pablo; Zahreddine, Nada et al. (2018) Should Clinicians Split or Lump Psychiatric Symptoms? The Structure of Psychopathology in Two Large Pediatric Clinical Samples from England and Norway. Child Psychiatry Hum Dev 49:607-620
Villalta, L; Smith, P; Hickin, N et al. (2018) Emotion regulation difficulties in traumatized youth: a meta-analysis and conceptual review. Eur Child Adolesc Psychiatry 27:527-544
Brislin, Sarah J; Patrick, Christopher J; Flor, Herta et al. (2018) Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project. Assessment :1073191118759748
Keren, Hanna; O'Callaghan, Georgia; Vidal-Ribas, Pablo et al. (2018) Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies. Am J Psychiatry :appiajp201817101124
Asarnow, Joan; Bloch, Michael H; Brandeis, Daniel et al. (2018) Special Editorial: Open science and the Journal of Child Psychology & Psychiatry - next steps? J Child Psychol Psychiatry 59:826-827

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