Under NCT03388606, we have: 1. Screened: 763 potential MDD patients, 200 HVs 2. Enrolled: 104 MDD patients, 70 HVs (including in other protocols) 3. Scanned: 452 MDD and HVs in total, including repeated scans on same individual as part of follow-up. 4. Increased inpatient activity: this protocol has already accounted for nearly 500 inpatient days 5. Continued outpatient activity: this protocol has seen over 200 more outpatient visits than the program recorded in FY17 for the same time period. 6. Published several papers in the last year The most notable include two last-author papers in the American Journal of Psychiatry (Pornpattatanangkul et al 2019, JAMA Psychiatry) and a trial paper (Towbin et al 2019 JAACAP).

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Budget End
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
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Stringaris, Argyris; Vidal-Ribas, Pablo; Brotman, Melissa A et al. (2018) Practitioner Review: Definition, recognition, and treatment challenges of irritability in young people. J Child Psychol Psychiatry 59:721-739
Vidal-Ribas, Pablo; Brotman, Melissa A; Salum, Giovanni A et al. (2018) Deficits in emotion recognition are associated with depressive symptoms in youth with disruptive mood dysregulation disorder. Depress Anxiety 35:1207-1217
Daley, David; Van Der Oord, Saskia; Ferrin, Maite et al. (2018) Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder. J Child Psychol Psychiatry 59:932-947
Kircanski, Katharina; White, Lauren K; Tseng, Wan-Ling et al. (2018) A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 75:631-639
Keren, Hanna; Chen, Gang; Benson, Brenda et al. (2018) Is the encoding of Reward Prediction Error reliable during development? Neuroimage 178:266-276
Barker, Edward D; Walton, Esther; Cecil, Charlotte A M et al. (2018) A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder. Child Dev 89:1839-1855
Humphreys, Kathryn L; Schouboe, Sophie N F; Kircanski, Katharina et al. (2018) Irritability, Externalizing, and Internalizing Psychopathology in Adolescence: Cross-Sectional and Longitudinal Associations and Moderation by Sex. J Clin Child Adolesc Psychol :1-9
Wesselhoeft, Rikke; Stringaris, Argyris; Sibbersen, Christian et al. (2018) Dimensions and subtypes of oppositionality and their relation to comorbidity and psychosocial characteristics. Eur Child Adolesc Psychiatry :
Fernández de la Cruz, Lorena; Vidal-Ribas, Pablo; Zahreddine, Nada et al. (2018) Should Clinicians Split or Lump Psychiatric Symptoms? The Structure of Psychopathology in Two Large Pediatric Clinical Samples from England and Norway. Child Psychiatry Hum Dev 49:607-620
Villalta, L; Smith, P; Hickin, N et al. (2018) Emotion regulation difficulties in traumatized youth: a meta-analysis and conceptual review. Eur Child Adolesc Psychiatry 27:527-544

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