Post-mortem studies in psychiatric disorders antemies to be a useful method for testing hypotheses. New findings include the following: (1) Decreased tritiated clonidine binding in the locus coeruleus of schizophrenic patients; (2) Increased methionine-enkephalin in the substantia nigra of schizophrenic patients; (3) Increased serotonin (5-HT) and 5-hydroxy-indoleacetic acid (5-HIAA) in basal ganglia and occipital cortex, respectively, in schizophrenic patients; and (4) Decreases in 5-HT and 5-HIAA in hypothalamus and nucleus accumbens, respectively in suicides.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002264-01
Application #
4696525
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code