Development of a neural prosthesis requires fabrication of a solid state device capable of recording information from neural tissue and stimulating it in a timely manner. We began this process by designing a simpler system to test and monitor cultured neural tissue. We identified some problems (such as suitable insulation for the device and corrosion in a critical part of the system) and we improved the tissue culture system to make the tests as realistic as possible. We have also worked with cultured retinal tissue in the system so that two-way communication could be achieved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002281-05
Application #
3921971
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Jia, Jie-Min; Zhao, Jun; Hu, Zhonghua et al. (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16:1627-36