Previously we have detected an NPY-like material, which is more hydrophilic than NPY, in the bovine adrenal gland. This NPY-like material has now been characterized to be identical to NPY(1-30). In this study, the distribution of NPY (1-30) in bovine adrenal glands was examined by radioimmunoassay. NPY (1-30) immunoreactivity was found in both cortex and medulla. In the adrenal medulla, the highest concentration was detected in chromaffin granules indicating that NPY(1-30) may be secreted. NPY (1-30) was also detected in the bovine brain. Whether this peptide represents a metabolite or an active form of an NPY-related peptide remains to be established. The proposed course of this study is to explore the biological activity of NPY (1-30).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002301-05
Application #
3880908
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code