The objective of this study is to search for evidence of anomalous innervation or regeneration in specific nuclei of schizophrenic brains. Formalin-fixed, paraffin-embedded, 50 mum matched sections of nucleus accumbens from eight age-and sex-matched control brains were used for studies of morphology and possible axonal sprouting. Using a monoclonal antibody against nonphosphorylated neurofilaments, we compared innervation patterns in limbic forebrain of schizophrenic and control brains at matched levels. A slight decrease in axons and a change in axon pattern was seen in the grouped schizophrenic specimens.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002457-06
Application #
3759433
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code