In this study we have investigated the effects of cocaine on the dopamine reuptake sites in the frontal cortex, as a function of time following chronic administration. The data indicated a 35% reduction in the number of dopamine uptake sites, 2 weeks following the discontinuation of cocaine treatment. The same magnitude of decrease was seen after 3 weeks, which persisted and increased to 50% after 6 weeks of withdrawal.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002484-03
Application #
3845286
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code