3-PPP, over .5 to 4.5 micromoles/kg, produced a dose-dependent decrease in locomotor activity, presumably by inhibiting the basal activity of ascending dopamine neurons. There was little difference between the groups treated chronically with saline or cocaine in terms of their response to 3-PPP. It appears, therefore, that there is no behavioral evidence for the presence of dopamine auto receptor subsensitivity following chronic cocaine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002534-04
Application #
3781445
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code