Since motor hyperexcitation is a frequent manifestation of psychotic states, the question has been raised as to whether physical hyperactivity may increase brain dopamine, thereby contributing to the brain dysfunction frequently seen in schizophrenia. In an attempt to answer this question, a rat model is being developed. The model would involve forced wheel running of Brown-Norway rats to the point exhaustion. Recovery would be monitored by open field behaviors. Biochemical studies involving dopamine, its metabolites, and other neurochemicals would help delineate the role of physical hyperactivity and concomitant stress on brain function. The wheel running apparatus has been constructed and the protocol has been approved by the ACUC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002547-03
Application #
3845338
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code