Abstract

Glucose transport into brain is mediated by facilitative transporter proteins (GLUT). Three GLUT isoforms are found in brain: GLUT1 is the blood brain barrier transporter, GLUT3 is the predominant neuronal transporter, and GLUT5 is found in microglia. The relationships between the concentrations and kinetic properties of these transporters and acute and chronic changes in glucose utilization are being studied in two separate series of experiments: 1.Chronic dehydration and rehydration, 2.Chronic hypoglycemia and chronic hyperglycemia in diabetic rats.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002733-02
Application #
6162944
Study Section
Special Emphasis Panel (LCM)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Koehler-Stec, E M; Li, K; Maher, F et al. (2000) Cerebral glucose utilization and glucose transporter expression: response to water deprivation and restoration. J Cereb Blood Flow Metab 20:192-200