Abstract

We focus on identifying candidate genes in restricted regions of the genome identified by linkage studies of complex genetic diseases, i.e. those which are not expected to show perfect cosegregation with any single locus. With our collaborators in NHGRI, we have identified transcripts in the vicinity of HPC1, a gene for early onset prostate cancer, and have obtained full-length cDNAs for more than ten new genes. We have begun to apply these methods to loci for bipolar disorder and schizophrenia. We have assembled unfinished sequence from the Human Genome Project to almost fully cover an approximately 15 cM region spanning the 13q32 region of chromosome 13 implicated by linkage analysis in both bipolar disorder and schizophrenia. We have identified more than 25 known genes and a growing number of new genes within this region. We have obtained full length or nearly full length cDNAs for a number of these new genes. A number of these genes are attractive candidates and we have begun to characterize polymorphisms within these candidate genes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002774-03
Application #
6501274
Study Section
(LG)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ferraren, Dilberto O; Liu, Chunyu; Badner, Judith A et al. (2005) Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 133:12-7
Hattori, Eiji; Liu, Chunyu; Badner, Judith A et al. (2003) Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72:1131-40
Liu, Chunyu; Bonner, Tom I; Nguyen, Tu et al. (2003) DNannotator: Annotation software tool kit for regional genomic sequences. Nucleic Acids Res 31:3729-35
Bowery, N G; Bettler, B; Froestl, W et al. (2002) International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function. Pharmacol Rev 54:247-64
Stephan, Dietrich A; Howell, Gareth R; Teslovich, Tanya M et al. (2002) Physical and transcript map of the hereditary prostate cancer region at xq27. Genomics 79:41-50
Spedding, M; Bonner, T I; Watson, S P (2002) International Union of Pharmacology. XXXI. Recommendations for the nomenclature of multimeric G protein-coupled receptors. Pharmacol Rev 54:231-2
Sood, R; Bonner, T I; Makalowska, I et al. (2001) Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. Genomics 73:211-22
Carpten, J D; Makalowska, I; Robbins, C M et al. (2000) A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region. Genomics 64:14-Jan
Sood, R; Makalowska, I; Carpten, J D et al. (2000) The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. Biochim Biophys Acta 1491:285-8