The application of the SSES SEM-based analytic approach to neuroscience primarily involves collaborating with neuroscientists in developing and carrying out analyses testing their hypotheses and elucidating their data when more traditional forms of analysis are inadequate. One such longstanding collaboration is with the NINDS Cognitive Neuroscience Section (CNS). The collaboration?s centers on the analysis of longitudinal data from the Vietnam Head Injury Study (VHIS)-- an intensive long term study of the effects of penetrating head injury that includes matched normal controls. Our collaboration?s present focus is on a survey, based on the SSES longitudinal survey, that the CNS is carrying out as part of the present wave of VHIS data collection. Analyzed in conjunction with other VHIS data these survey data will permit the examination of the interactions among environmental demands, brain injury location and APOE and COMT alleles in affecting psychological functioning. A second collaboration is with the NIMH Laboratory of Clinical Science. Through SEM and related analyses we reliably ascertained the latent factorial structure of Obsessive Compulsive Disorder (OCD), used the factors? pattern of interrelationships to distinguish different OCD subgroups and linked group membership to differences in familial incidence and comorbidity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002785-05
Application #
7312876
Study Section
(SSES)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2006
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Rosen, V M; Caplan, L; Sheesley, L et al. (2003) An examination of daily activities and their scripts across the adult lifespan. Behav Res Methods Instrum Comput 35:32-48
Jeffries, K J; Schooler, C; Schoenbach, C et al. (2002) The functional neuroanatomy of Tourette's syndrome: an FDG PET study III: functional coupling of regional cerebral metabolic rates. Neuropsychopharmacology 27:92-104